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AstraZeneca’s Lynparza shows positive effect in BRCA-mutated ovarian cancer (NYSE:AZN)

AstraZeneca (NYSE:AZN) and Merck (NYSE:MRK) announce that LYNPARZA demonstrated a long-term progression-free survival (PFS) benefit versus placebo as a 1st-line maintenance treatment in patients with newly diagnosed, advanced BRCA-mutated (BRCAm) ovarian cancer who had a complete or partial response following platinum-based chemotherapy.

Five-year follow-up data from the Phase III SOLO-1 trial showed LYNPARZA reduced the risk of disease progression or death by 67% (based on a hazard ratio [HR] of 0.33; 95% confidence interval [CI] 0.25-0.43) and improved PFS to a median of 56.0 months versus 13.8 months for placebo.

At five years, 48.3% of patients treated with LYNPARZA remained free from disease progression versus 20.5% on placebo.

The median duration of treatment with LYNPARZA was 24.6 months versus 13.9 months with placebo.

The safety profile of LYNPARZA was consistent with previous observations. 12% of patients on LYNPARZA discontinued treatment due to an adverse events.

The results were presented on at the 2020 European Society of Medical Oncology (ESMO) virtual congress.

See AZN’s total return performance vs. MRK and S&P500 over the past one year. 

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